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Patients with a history of hypersensitivity to any of the ingredients of Herbesser R 100/R 200.
Patients with severe congestive heart failure. (The symptoms may be exacerbated.)
Patients with 2nd- or 3rd-degree atrioventricular block or sick sinus syndrome [continuous sinus bradycardia (<50 beats/min), sinus arrest, sinoatrial block, etc]. (The inhibitory action on sinus rhythm and cardiac conduction of the drug may occur excessively.)
Use in pregnancy: Herbesser R 100/R 200 is contraindicated to pregnant women and women who may possibly be pregnant. [Animal studies have shown that the drug has teratogenic effects (mice: Abnormality of skeleton, dysplasia) and embryotoxicity (mice, rats: Lethality)].
